KMID : 0357920090430050408
|
|
Korean Journal of Pathology 2009 Volume.43 No. 5 p.408 ~ p.412
|
|
Significance of the Expression of Cathepsins B, H, & L in Colonic Epithelial Neoplasms
|
|
Sim Jae-Young
Lee Mi-Ja Kee Keun-Hong
|
|
Abstract
|
|
|
Background: Cathepsin is associated with tumorigenesis, tumor invasion and metastasis through its ability to induce degradation of extracellular matrix components.
Methods: To investigate the correlation between cathepsin expression and tumor progression, invasion depth or nodal metastasis, immunohistochemical staining for cathepsins B, H and L were done on 20 hyperplastic polyps, 48 adenomas, and 67 adenocarcinomas of the colon. Evaluation of the expression of cathepsins B, H and L was based on the percentage of neoplastic cells that stained positive for any given cathepsin.
Results: Cathepsin B expression was significantly higher in adenocarcinomas than adenomas (29.33 vs 5.48%), but was not associated with the degree of differentiation, depth of invasion and nodal status of the tumors. Expression of cathepsins H and L was absent or low in both adenomas and adenocarcinomas.
Conclusions: We suggest that cathepsin B is involved in progression of a subset of colonic adenomas, while cathepsins H and L are not.
|
|
KEYWORD
|
|
Cathepsin, Colon, Adenoma, Adenocarcinoma
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|